Bronch-START (2021-22): This multi-centre prospective observational cohort study will use a well-established research network (Paediatric Emergency Research in the UK and Ireland, PERUKI) to report in real time cases of RSV infection in children aged under two years, through the collection of essential, but non-identifying patient information. Forty-five centres will gather initial data on age, index of multiple deprivation quintile, clinical features on presentation, and co-morbidities. Each case will be followed up at seven days to identify treatment, viral diagnosis and outcome. Information be released on a weekly basis and used to support clinical decision making.
CRAFFT (Children’s Radius Acute Fracture Fixation Trial) (2019-23): A multi-centre prospective randomised
non-inferiority trial of surgical reduction versus non-surgical casting for
displaced distal radius fractures in children.
Evaluating ICON (2021-23): We want to know whether abusive head trauma happens less often in areas offering the ICON programme compared to areas that do not, and to understand what factors influence its impact.
Using existing health records, we will count the number of cases of abusive head trauma before and after the introduction of the ICON programme. We will ask families and healthcare professionals what they know about ICON and their views on it, including how to make it available and understood by as many families as possible.
This will help us find out the best way to take the ICON messages to more areas of the UK.
Button Battery Surveillance (2021-23): BPSU surveillance of the unintentional ingestion, inhalation or insertion of button batteries in children requiring removal or attempted removal commenced in February 2021. This study will help inform services for the prevention and treatment of children who have accidentally swallowed or choked on button batteries.
Mellitus in children and young people presenting to emergency departments
during the SARS-CoV-2 pandemic. (the DIMPLES study) (2021):
This multi-centre retrospective observational study, running in 40 sites across the UK & Ireland, aims to determine whether there was an increase in incidence of new onset or decompensation of diabetes mellitus during the COVID pandemic. Analysis of secondary outcomes, including presentation patterns, will inform decision making processes for clinicians.
Abusive head trauma in infants (2020-22): This study, consisting of a systematic review and data linkage, aims to determine which features are predictive of an increased risk of abusive head injury in the first year of life.
Predicting post-concussion symptoms in paediatric patients (2020-22): This systematic review and data linkage study aims to determine which factors are most predictive of increased risk for developing post-concussion syndrome in children and young people.
EcLiPSE (2015-18): The study aimed to find out whether children and young people with long lasting seizures should be treated with phenytoin or levetiracetam (brand name Keppra) in an emergency setting.
CAP-IT (2017-19): The CAP-IT trial, a factorial non-inferiority randomised controlled trial, aimed to determine whether low dose and short duration of treatment with amoxicillin was as effective as high dose, and long duration of treatment, in the management of community acquired pneumonia in young children.
Neonatal presentations to Emergency Care (2016): This retrospective observational study aimed to investigate attendance patterns to Emergency Care of babies under one month of age, in order to inform service planning for this vulnerable cohort of patients.
Petechiae in Children (PiC) study (2017-19): This prospective observational multicentre study aimed to determine the performance accuracy of existing clinical practice guidelines for the Emergency Care of children and young people presenting with non-blanching rashes in the context of feverish illness, in order to identify the optimal tool for clinical use. Secondary aims included the evaluation of biomarkers, including procalcitonin, for identifying patients at greater risk of invasive disease.
Paediatric Major Incident Triage (2021-22): This study aims identify the ideal major incident triage tool for use in children, through analysis of existing large datasets, machine learning techniques, and Delphi consensus methodology