Kidney disease research

There are many research projects which take place across Bristol.

Current research projects

  • Reducing inequity in transplantation: The ASK Trial: improving AccesS to Kidney transplantation https://doi.org/10.1186/ISRCTN10989132
  • Bailey PK, Ben-Shlomo Y, Caskey FJ et al. Development of an intervention to improve access to living-donor kidney transplantation (the ASK study). PLoS One. 2021 Jun 25;16(6):e0253667
  • Preparing older people for kidney failure treatments: the Prepare for Kidney Care trial https://doi.org/10.1186/ISRCTN17133653 A national trial which aims to help older people with kidney disease make the right decision for them when their kidney function is getting very low.
  • Comparing different types of dialysis treatment: the H4RT trial https://doi.org/10.1186/ISRCTN10997319 A national trial comparing different types of blood filtering treatments for kidney failure.
  • Understanding the management of and outcomes following heart attacks in people with kidney disease: Inequities in heart-kidney care: Why are people with kidney disease at increased risk of death and disability after a heart attack?
    https://fundingawards.nihr.ac.uk/award/NIHR300906
  • Understanding treatment preferences of older Patients and their families deciding between dialysis and comprehensive conservative Care for Kidney failure: the UNPACK study
    https://fundingawards.nihr.ac.uk/award/DRF-2017-10-127

Previous research projects

Research to understand transplant inequity and to identify barriers to kidney donation and transplantation:

  • Taylor DM, Bradley JA, Bradley C et al. Limited health literacy is associated with reduced access to kidney transplantation. Kidney Int. 2019 May;95(5):1244-1252.
  • Taylor DM, Fraser SDS, Bradley JA. A Systematic Review of the Prevalence and Associations of Limited Health Literacy in CKD. Clin J Am Soc Nephrol. 2017 Jul 7;12(7):1070-1084.
  • Bailey PK, Tomson CRV, MacNeill S. A multicenter cohort study of potential living kidney donors provides predictors of living kidney donation and non-donation. Kidney Int. 2017 Nov;92(5):1249-1260.
  • Bailey PK, Ben-Shlomo Y, Tomson CR, Owen-Smith A. Socioeconomic deprivation and barriers to live-donor kidney transplantation: a qualitative study of deceased-donor kidney transplant recipients. BMJ Open. 2016 Mar 2;6(3):e010605.
  • Bailey PK, Caskey FJ, MacNeill S, Tomson CRV, Dor FJMF, Ben-Shlomo Y. Mediators of Socioeconomic Inequity in Living-donor Kidney Transplantation: Results From a UK Multicenter Case-Control Study. Transplant Direct. 2020 Mar 13;6(4):e540.
  • Wong K, Owen-Smith A, Caskey F et al. Investigating Ethnic Disparity in Living-Donor Kidney Transplantation in the UK: Patient-Identified Reasons for Non-Donation among Family Members. J Clin Med. 2020 Nov 21;9(11):3751

Analysis around the prescription of RAS blockers and risk of acute kidney injury:

  • Scott J, Jones T, Redaniel MT et al. Estimating the risk of acute kidney injury associated with use of diuretics and renin angiotensin
    aldosterone system inhibitors: A population based cohort study using the clinical practice research datalink. BMC Nephrol. 2019;20(1):481.
  • A systematic review, undertaken by NIHR Applied Research Collaboration West (ARC West), into reducing harm from acute kidney injury and developing an effective sick day rule. ‘Morden A, Horwood J, Whiting P et al.
  • The risks and benefits of patients temporarily discontinuing medications in the event of an intercurrent illness: a systematic review protocol. Morden, A, Horwood, J, Syst Rev 2015;4:139
  • The risks and benefits of patients temporarily discontinuing medications in the event of an intercurrent illness: a systematic review protocol. Morden, A, Horwood, J, Syst Rev 2015;4:139
  • Establishing teleclinics for kidney transplant recipients: Udayaraj U, Watson O, Ben-Shlomo Y et al. Establishing a tele-clinic service for kidney transplant recipients through a patient-codesigned quality improvement project. BMJ Open Qual. 2019 Apr 8;8(2):e000427.
  • A systematic review and meta-analysis on the question What are the risks and benefits of temporarily discontinuing medications to prevent acute kidney injury? Whiting P, Morden A, Tomlinson LA et al.
  • What are the risks and benefits of temporarily discontinuing medications to prevent acute kidney injury? A systematic review and meta-analysis. BMJ Open 2017;7(4):e012674

Kidney disease research: Who’s involved

  • Dr Dominic Taylor, Consultant Nephrologist at North Bristol NHS Trust
  • Professor Fergus Caskey, Professor of Renal Medicine, University of Bristol and Consultant Nephrologist at North Bristol NHS Trust
  • Professor Yoav Ben-Shlomo, Clinical Epidemiologist, University of Bristol
  • Dr Pippa Bailey, Consultant Senior Lecturer in Renal Medicine, University of Bristol

NIHR ARC West

The following researchers from NIHR ARC West have worked with the Kidney Disease HIT:

  • Penny Whiting
  • Jeremy Horwood
  • Theresa Redaniel
  • Tracey Stone