Dementia research badly affected by COVID-19

  • 4th August 2020

The development of new diagnostic tests and
treatments for dementia is likely to be severely hampered due to the COVID-19
pandemic, as the charities that traditionally fund such work have lost much of
their income, according to speakers at recent webinars organised by the
Dementia Health Integration Team and the Alzheimer’s Research UK (ARUK) Bristol
and Bath Network Centre.

The loss of income through fundraising for
the whole medical research charity sector is estimated to be 38%, which will
result in a dramatic fall in research spending of £310million over the next
year, according to Dr Sara Imarisio, head of Strategic Initiatives for the
national UK charity Alzheimer’s Research UK.

This is due to cancellation of
fundraising events and other activities, and staff being furloughed. ARUK is
facing an income shortfall of around 45%, and like other medical charities having
to make cuts; its usual Grant Review Board meetings that were due to be held in
June 2020 and January 2021 have been cancelled, and the charity will not be
awarding any new research grants until after June 2021.

This could be especially difficult for
researchers on short-term contracts, who face not only delays in completion of
their laboratory or clinical research but also fewer publications and a
scarcity of new contracts, said Amarisio. She advised that researchers should
make any future funding applications as strong as possible ‘just be prepared –
you have to give your very best because we are expecting a level of competition
that is probably unusual.’

Similarly, the charity BRACE, which funds
dementia research mainly in the southwest has also had to freeze its grant
application process until 2021. “The impact on the research we fund has been
huge,” said Mark Poarch, BRACE Chief Executive Officer.

On a more positive note, however, BRACE had
already committed a £140,000 grant prior to lockdown for continuation of the
Southwest Dementia Brain Bank from May 2020 to autumn 2021, and to support the ReMemBr
Group clinical research team at Southmead Hospital, including a research nurse
and clinic coordinator. https://www.bristolhealthpartners.org.uk/latest-news/2020/07/15/key-dementia-research-facility-protected-thanks-to-brace/1347

“I feel very positive about the future of
BRACE and the way that we’re rising to this challenge but raising the money we
need to meet those challenges next year is going to be a big challenge for us,”
Poarch warned. BRACE will be open to receiving new funding applications from researchers
from November 2020 onwards, for consideration in February 2021.

Meanwhile, ARUK emphasized that it would allow
flexibility for currently funded researchers, including project and studentship
extensions and delayed starts to new projects. The charity is also continuing
to offer the David Hague Early Career Investigator of the Year Award of £25,000
(deadline 25 September 2020), and the Race Against Dementia early career
fellowships of up to £500,000 for 5 years, in partnership with charity set up
by Formula One racing legend Jackie Stewart (applications deadline, January 2021).

“If [there’s] someone who springs to mind, please encourage them to apply or apply yourself if you’ve got three excellent
outputs from your work – I’m sure there are lots of you out there”, said Honor
Pollard, ARUK Science Communications Officer.

ARUK will also continue to
support its regional network centres with pump-priming grants, travel grants
and networking and careers building activities – including for Bristol and Bath
members, many of whom are involved in the Dementia Health Integration Team.

The impact of COVID-19 has been felt
particularly in the area of clinical trials. As many as 70% of trials funded by
medical charities have been stopped, paused or delayed due to the pandemic, and
there are concerns that many will not be able to restart due to lack of
funding. More than one-third (58) of NHS-funded non-commercial clinical trials remain
paused due to COVID-19-related safety restrictions on volunteers and staff, and
staff being redeployed to ‘front line’ NHS work.

However, plans are underway
for a phased restarting of clinical trials – https://www.nihr.ac.uk/documents/restart-framework/24886
and the start of new trials, according to Heather Tinkler, Research Delivery
Manager, Clinical Research Network West of England.

Further links:

ARUK position statement for researchers

Race Against Dementia Early Career
Fellowship

https://www.alzheimersresearchuk.org/grants/race-dementia-fellowship/

David Hague Early Career Investigator of
the Year Award

https://www.alzheimersresearchuk.org/research/for-researchers/research-opportunities/early-career-award/

ARUK Network Centres

https://www.Alzres.uk/network

Webinar links

Impact of covid19 on dementia research, 23
June 2020

https://uob-my.sharepoint.com/:v:/g/personal/jc14922_bristol_ac_uk/EYR60JMI3lVBjDQ6-h8NeRYBlOwwlpxp8uc9txCn_-ZIsQ?e=RtohcA

Opportunities for Early Career Researchers,
21 July 2020

https://uob-my.sharepoint.com/:v:/g/personal/jc14922_bristol_ac_uk/Eb-1Co1X3_RJj8YmZqxWkjMB_LRjeoG7UXEkBdITW_BAcw?e=rozGVM

CRN West of England

https://local.nihr.ac.uk/lcrn/west-of-england/